Multiple Updates in MySQL

I know that you can insert multiple rows at once, is there a way to update multiple rows at once (as in, in one query) in MySQL?

Edit: For example I have the following

Name   id  Col1  Col2

Row1   1    6     1

Row2   2    2     3

Row3   3    9     5

Row4   4    16    8

I want to combine all the following Updates into one query

UPDATE table SET Col1 = 1 WHERE id = 1;

UPDATE table SET Col1 = 2 WHERE id = 2;

UPDATE table SET Col2 = 3 WHERE id = 3;

UPDATE table SET Col1 = 10 WHERE id = 4;

UPDATE table SET Col2 = 12 WHERE id = 4;

Yes, that's possible - you can use INSERT ... ON DUPLICATE KEY UPDATE.

 example:

INSERT INTO table (id,Col1,Col2) VALUES (1,1,1),(2,2,3),(3,9,3),(4,10,12)

ON DUPLICATE KEY UPDATE Col1=VALUES(Col1),Col2=VALUES(Col2);